


The participants were followed for about 20 years, during which 233 of the participants died of various causes. A score of zero meant no wrinkles, while a score of 3 meant "numerous deep wrinkles." The participants underwent an exam in which doctors assessed their forehead wrinkles and assigned the participants a score based on the number and depth of the wrinkles. In the new study, the researchers analyzed data from more than 3,200 French adults who were ages 32, 42, 52 and 62 at the start of the study. Previous studies have found a link between other visible features - including male-pattern baldness, earlobe creases and xanthelasma (pockets of cholesterol under the skin) - and heart disease risk. Gregg Fonarow, a professor of cardiovascular medicine at the University of California, Los Angeles, who was not involved with the study. The exact reason for the link is unknown, but "some factors that may lead to premature aging of the skin can contribute to premature aging of the arteries" and atherosclerosis, said Dr. "Forehead wrinkles may be a marker of atherosclerosis," or hardening of the arteries due to plaque buildup, Esquirol said. But if a person has a lot of deep forehead wrinkles, it could raise a red flag, they said. Moreover, the researchers noted that looking at forehead wrinkles wouldn't take the place of assessing people for classic risk factors, such as high blood pressure and cholesterol levels.
